A new study suggests that snoring may increase the risk of developing keratoconus (KCN). Researchers used a genetic analysis technique called Mendelian Randomization (MR) to investigate whether snoring plays a direct role in causing keratoconus. Their findings, published in the journal Cornea, provide strong genetic evidence linking snoring to an increased likelihood of developing the condition. 

Understanding the Study 

The researchers analyzed data from over 218,000 individuals in a UK biobank to identify genetic markers associated with snoring. They then compared these genetic markers to data from over 209,000 individuals, including 311 people diagnosed with keratoconus. By using advanced statistical methods, they found a causal link between snoring and an increased risk of keratoconus. However, they did not find evidence that keratoconus causes snoring. 

Why Does This Matter? 

Keratoconus is a progressive corneal disease that can cause significant vision loss if left untreated. While previous studies have suggested a connection between obstructive sleep apnea (OSA) and keratoconus, this research strengthens the case that snoring itself may be a contributing factor. 

One possible explanation is that snoring and OSA lead to intermittent low oxygen levels (hypoxia), which may weaken the cornea over time. Hypoxia has been linked to increased oxidative stress and inflammation, both of which are known to play a role in keratoconus progression. 

What Can Patients Do? 

If you have keratoconus and snore frequently, you may want to discuss your sleep health with your doctor. Since snoring and OSA can affect overall health, addressing sleep-related issues may not only improve your well-being but could also help slow the progression of keratoconus. 

A Step Toward Prevention? 

The study’s authors believe their findings could open new avenues for preventing keratoconus by targeting snoring and sleep-related breathing disorders. While more research is needed to fully understand this connection, these results suggest that taking care of your sleep health may be an important part of managing keratoconus. 

Reference: 

Chen X, Liu S, Liu C, et al. Genetic Evidence Supporting a Causal Role of Snoring in Keratoconus: A Bidirectional Mendelian Randomization Study. Cornea. 2025;44(2):221-225.